[Morphological alterations of lymph nodes and thymus during the early course of SIV infection of rhesus monkeys]. 1991

J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
Pathologisches Institut Würzburg.

Rhesus monkeys (M. mulatta) were i.v. infected with SIV mac251. Three phases of lymph node changes were observed. 1: physiological follicular hyperplasia (3 and 6 weeks p.i.). 2: Alterations of germinal centers: loss of follicular mantle zone, fragmentation or sclerosis (12 and 24 weeks p.i.). 3: Partial depletion of T-lymphocytes, accumulation of plasma cells, increased numbers of syncytial giant cells, hemophgocytosis in the sinuses (about 1 year p.i.). The thymus of the juvenile animals showed first changes 12 and 24 weeks after infection with focal loss of immature (and Ki-67 positive) cortical thymocytes, leading to severe accidental involution of the thymuses one year after infection and reduced numbers of Hassalls corpuscles. These investigations show the value of this animal model for the study of morphology and pathogenesis of AIDS.

UI MeSH Term Description Entries
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008253 Macaca mulatta A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans. Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D013950 Thymus Gland A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat. Thymus,Gland, Thymus,Glands, Thymus,Thymus Glands
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D016097 Simian Acquired Immunodeficiency Syndrome Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS. AIDS, Simian,SAIDS,Simian AIDS,Simian Acquired Immune Deficiency Syndrome,Simian Acquired Immuno-Deficiency Syndrome,AIDSs, Simian,Simian AIDSs,Simian Acquired Immuno Deficiency Syndrome
D016130 Immunophenotyping Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry. Lymphocyte Immunophenotyping,Lymphocyte Subtyping,Immunologic Subtyping,Immunologic Subtypings,Lymphocyte Phenotyping,Subtyping, Immunologic,Subtypings, Immunologic,Immunophenotyping, Lymphocyte,Immunophenotypings,Immunophenotypings, Lymphocyte,Lymphocyte Immunophenotypings,Lymphocyte Phenotypings,Lymphocyte Subtypings,Phenotyping, Lymphocyte,Phenotypings, Lymphocyte,Subtyping, Lymphocyte,Subtypings, Lymphocyte

Related Publications

J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
February 1995, AIDS research and human retroviruses,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
January 1994, Research in virology,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
June 1998, Experimental parasitology,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
January 1995, Research in virology,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
January 1996, Research in virology,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
October 2005, AIDS (London, England),
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
September 2021, Tropical biomedicine,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
October 2003, Pathologica,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
January 1994, Journal of medical primatology,
J G Müller, and C Stahl-Hennig, and A Rethwilm, and C Kneitz, and T Kerkau, and B Schmauser, and C Schindler, and V Krenn, and V terMeulen, and H K Müller-Hermelink
June 2018, Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology,
Copied contents to your clipboard!