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Endothelin-1 (ET-1) induced a concentration- and time-dependent increase in arachidonic acid release from guinea pig alveolar macrophages, a maximum being reached at 1 nM ET-1. Regarding the time-course study, maximal release of arachidonic acid was observed after 30 s of incubation with ET-1 and then followed by a marked decrease, suggesting a reuptake of free arachidonic acid. ET-1 (0.1-10 nM) induced a concentration- and time-dependent release of TXB2, the stable metabolite of TXA2, evaluated by an ELISA technique. Maximum release was also obtained with 1 nM ET-1 but only after a 1-min incubation period. By contrast, ET-1 (1 pM-1 microM) did not stimulate the release of superoxide anion at any time point of the kinetic study. These results suggests that ET-1 may activate guinea pig alveolar macrophages, probably through a mechanism involving the arachidonic acid pathway.
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
January 1981,
Journal of immunology (Baltimore, Md. : 1950),
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
August 1972,
Experientia,
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
April 1978,
The American review of respiratory disease,
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
January 1998,
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
January 1990,
Pharmacological research,
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
November 1997,
American journal of respiratory and critical care medicine,
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
January 1977,
Cellular immunology,
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
November 1981,
Journal of the Reticuloendothelial Society,
V Millul, and
V Lagente, and
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E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
December 1986,
Journal of immunology (Baltimore, Md. : 1950),
V Millul, and
V Lagente, and
O Gillardeaux, and
E Boichot, and
B Dugas, and
J M Mencia-Huerta, and
G Béréziat, and
P Braquet, and
J Masliah
January 1989,
Agents and actions,
