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Using highly specific and sensitive radioimmunoassays (RIAs) for endothelin-1 (ET-1) and endothelin-3 (ET-3), we have determined the concentrations of ET-1- and ET-3-like immunoreactivities (LI) in human cerebrospinal fluid (CSF). The concentration of ET-3-LI (82.5 +/- 4.8 pg/ml) was about 1.5-fold greater than that of ET-1-LI (34.3 +/- 1.3 pg/ml). There was no significant correlation between ET-1-LI and ET-3-LI concentrations in human CSF (r = 0.44). Reverse-phase high-performance liquid chromatography (HPLC) revealed a single major component of ET-1-LI and ET-3-LI coeluting with authentic ET-1 and ET-3, respectively. It is suggested that ET-1 and ET-3 play a neuropeptide-like role in the central nervous system.
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
October 1981,
Brain research,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
December 1990,
The Journal of clinical endocrinology and metabolism,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
January 1994,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
June 1989,
International journal of peptide and protein research,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
January 1999,
Neuroscience,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
April 1993,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
January 1997,
Peptides,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
January 1998,
Peptides,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
July 1992,
Journal of reproduction and fertility,
K Ando, and
Y Hirata, and
K Togashi, and
M Kawakami, and
F Marumo
January 1990,
Annals of medicine,
