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Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep. 2007

Caroline Leroux, and Nicolas Girard, and Vincent Cottin, and Timothy Greenland, and Jean-François Mornex, and Fabienne Archer
Université de Lyon 1, INRA, UMR754, Ecole Nationale Vétérinaire de Lyon, IFR 128, F-69007, Lyon, France. caroline.leroux@univ-lyon1.fr

Jaagsiekte Sheep Retrovirus (JSRV) is a betaretrovirus infecting sheep. This virus is responsible for a pulmonary adenocarcinoma, by transformation of epithelial cells from the bronchioli and alveoli. This animal cancer is similar to human bronchioloalveolar cancer (BAC), a specific form of human lung cancer for which a viral aetiology has not yet been identified. JSRV interacts with target cells through the membrane receptor Hyal2. The JSRV genome is simple and contains no recognised oncogene. It is now well established that the viral envelope protein is oncogenic by itself, via the cytoplasmic domain of the transmembrane glycoprotein and some domains of the surface glycoprotein. Activation of the PI3K/Akt and MAPK pathways participates in the envelope-induced transformation. Tumour development is associated with telomerase activation. This review will focus on the induction of cancer by JSRV.

UI MeSH Term Description Entries
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D011648 Pulmonary Adenomatosis, Ovine A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS. Adenomatosis, Pulmonary, Ovine,Carcinoma, Ovine Pulmonary,Jaagsiekte,Adenomatosis, Ovine Pulmonary,Ovine Pulmonary Adenomatosis,Ovine Pulmonary Carcinoma,Pulmonary Ovine Adenomatosis,Adenomatoses, Ovine Pulmonary,Adenomatoses, Pulmonary Ovine,Adenomatosis, Pulmonary Ovine,Carcinomas, Ovine Pulmonary,Ovine Adenomatoses, Pulmonary,Ovine Adenomatosis, Pulmonary,Ovine Pulmonary Adenomatoses,Ovine Pulmonary Carcinomas,Pulmonary Adenomatoses, Ovine,Pulmonary Carcinoma, Ovine,Pulmonary Carcinomas, Ovine,Pulmonary Ovine Adenomatoses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D022141 Jaagsiekte sheep retrovirus A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE). Ovine pulmonary adenocarcinoma virus,JSRV,Jaagsiekte Retrovirus,Jaagsiekte Retroviruses,Jaagsiekte sheep retroviruses,sheep retrovirus, Jaagsiekte

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