BIOMAT Database Logo BIOMAT Database Logo

Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. 2007

J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Nutritional Biochemistry and Carcinogenesis Laboratory, Department of Food and Animal Sciences, Alabama A&M University, Normal, AL 35762, United States.

Phytochemicals contribute to the vibrant colors of fruits and it is suggested that the darker the fruit the higher the antioxidative or anticarcinogenic properties. In this study we investigated the possible effects of blueberries (BLU), blackberries (BLK), plums (PLM), mangoes (MAN), pomegranate juice (POJ), watermelon juice (WMJ) and cranberry juice (CBJ) on azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Forty-eight male Fisher 344 rats were randomly assigned to eight groups (n=6). The groups were fed AIN-93G as a control (C) diet, the rats fed fruits received AIN-93G+5% fruits and the groups that were given fruits juices received 20% fruit juice instead of water. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at seventh and eighth weeks of age. At 17th week of age, the rats were killed by CO(2) asphyxiation. Total ACF numbers (mean+/-SEM) in the rats fed CON, BLU, BLK, PLM, MNG, POJ, WMJ and CBJ were 171.67+/-5.6, 11.33+/-2.85, 24.0+/-0.58, 33.67+/-0.89, 28.67+/-1.33, 15.67+/-1.86, 24.33+/-3.92 and 39.0+/-15.31. Total glutathione-S-transferase (GST) activity (mICROmol/mg) in the liver of the rats fed fruits (except BLK) and fruit juices were significantly (p<0.05) higher in the rats fed fruits and fruit juices compared with the control. Our findings suggest that among the fruits and fruit juices, BLU and POJ contributed to significant (P<0.05) reductions in the formation of AOM-induced ACF.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D011230 Precancerous Conditions Pathological conditions that tend eventually to become malignant. Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D011916 Rats, Inbred F344 An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. Fischer Rats,Rats, Inbred CDF,Rats, Inbred Fischer 344,Rats, F344,Rats, Inbred Fisher 344,CDF Rat, Inbred,CDF Rats, Inbred,F344 Rat,F344 Rat, Inbred,F344 Rats,F344 Rats, Inbred,Inbred CDF Rat,Inbred CDF Rats,Inbred F344 Rat,Inbred F344 Rats,Rat, F344,Rat, Inbred CDF,Rat, Inbred F344,Rats, Fischer
D003110 Colonic Neoplasms Tumors or cancer of the COLON. Cancer of Colon,Colon Adenocarcinoma,Colon Cancer,Cancer of the Colon,Colon Neoplasms,Colonic Cancer,Neoplasms, Colonic,Adenocarcinoma, Colon,Adenocarcinomas, Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Adenocarcinomas,Colon Cancers,Colon Neoplasm,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon
D005638 Fruit The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds. Berries,Legume Pod,Plant Aril,Plant Capsule,Aril, Plant,Arils, Plant,Berry,Capsule, Plant,Capsules, Plant,Fruits,Legume Pods,Plant Arils,Plant Capsules,Pod, Legume,Pods, Legume
D005982 Glutathione Transferase A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite. Glutathione S-Alkyltransferase,Glutathione S-Aryltransferase,Glutathione S-Epoxidetransferase,Ligandins,S-Hydroxyalkyl Glutathione Lyase,Glutathione Organic Nitrate Ester Reductase,Glutathione S-Transferase,Glutathione S-Transferase 3,Glutathione S-Transferase A,Glutathione S-Transferase B,Glutathione S-Transferase C,Glutathione S-Transferase III,Glutathione S-Transferase P,Glutathione Transferase E,Glutathione Transferase mu,Glutathione Transferases,Heme Transfer Protein,Ligandin,Yb-Glutathione-S-Transferase,Glutathione Lyase, S-Hydroxyalkyl,Glutathione S Alkyltransferase,Glutathione S Aryltransferase,Glutathione S Epoxidetransferase,Glutathione S Transferase,Glutathione S Transferase 3,Glutathione S Transferase A,Glutathione S Transferase B,Glutathione S Transferase C,Glutathione S Transferase III,Glutathione S Transferase P,Lyase, S-Hydroxyalkyl Glutathione,P, Glutathione S-Transferase,Protein, Heme Transfer,S Hydroxyalkyl Glutathione Lyase,S-Alkyltransferase, Glutathione,S-Aryltransferase, Glutathione,S-Epoxidetransferase, Glutathione,S-Transferase 3, Glutathione,S-Transferase A, Glutathione,S-Transferase B, Glutathione,S-Transferase C, Glutathione,S-Transferase III, Glutathione,S-Transferase P, Glutathione,S-Transferase, Glutathione,Transfer Protein, Heme,Transferase E, Glutathione,Transferase mu, Glutathione,Transferase, Glutathione,Transferases, Glutathione
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
October 2008, Cancer prevention research (Philadelphia, Pa.),
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Dietary inulin suppresses azoxymethane-induced preneoplastic aberrant crypt foci in mature Fisher 344 rats.
September 2002, The Journal of nutrition,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Dietary inulin suppresses azoxymethane-induced aberrant crypt foci and colon tumors at the promotion stage in young Fisher 344 rats.
September 2002, The Journal of nutrition,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats.
January 2006, Nutrition and cancer,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Increased susceptibility of adult rats to azoxymethane-induced aberrant crypt foci.
December 2000, Cancer letters,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats.
July 2010, Molecular carcinogenesis,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Effect of dietary galacto-oligosaccharides on azoxymethane-induced aberrant crypt foci and colorectal cancer in Fischer 344 rats.
January 2001, Carcinogenesis,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats.
January 2008, Carcinogenesis,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
February 2002, Japanese journal of cancer research : Gann,
J Boateng, and M Verghese, and L Shackelford, and L T Walker, and J Khatiwada, and S Ogutu, and D S Williams, and J Jones, and M Guyton, and D Asiamah, and F Henderson, and L Grant, and M DeBruce, and A Johnson, and S Washington, and C B Chawan
Bifidobacterium longum and lactulose suppress azoxymethane-induced colonic aberrant crypt foci in rats.
March 1997, Carcinogenesis,
Copied contents to your clipboard!