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The activities of glycerol 3-phosphate dehydrogenase (EC 1.1.1.8), glycerol kinase (EC 2.7.1.30), lactate dehydrogenase (EC 1.1.1.27), "malic' enzyme (L-malate-NADP+ oxidoreductase; EC 1.1.1.40) and the beta-oxoacyl-(acyl-carrier protein) reductase component of the fatty acid synthetase complex were measured in nine hepatoma lines (8 in rats, 1 in mouse) and in the livers of host animals. With the single exception of Morris hepatoma 16, which had unusually high glycerol 3-phosphate dehydrogenase activity, the activities of glycerol 3-phosphate dehydrogenase and glycerol kinase were highly correlated in normal livers and hepatomas (r = 0.97; P less than 0.01). The activities of these two enzymes were not strongly correlated with the activities of any of the other three enzymes. The primary function of hepatic glycerol 3-phosphate dehydrogenase appears to be in gluconeogenesis from glycerol.
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
September 1980,
Brain research,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
June 1969,
Biochimica et biophysica acta,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
October 1997,
Nihon rinsho. Japanese journal of clinical medicine,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
August 1971,
Archives of biochemistry and biophysics,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
August 1971,
Archives of biochemistry and biophysics,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
February 1982,
Journal of neurochemistry,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
December 1990,
Journal of general microbiology,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
August 1971,
Archives of biochemistry and biophysics,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
January 1981,
Methods in enzymology,
J W Harding, and
E A Pyeritz, and
H P Morris, and
H B White
September 1974,
Biochimica et biophysica acta,
