-transparent.png){kind=logo}
Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication. 2007
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
Valeant Research & Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. egunic@ardeabio.com
A new series of heterobase-modified 2'-C-methyl ribonucleosides was synthesized and tested as inhibitors of hepatitis C virus (HCV) RNA replication. The nucleosides showed a weak inhibitory activity in a HCV replicon system (EC(50)=92 microM) and did not exhibit any cytotoxicity (CC(50)>300 microM). Cyclic monophosphate (cMP) prodrugs of the same nucleosides were synthesized and also tested in the HCV replicon system. Prodrugs exhibited strong potency (EC(50)=0.008 microM) without significant cytotoxicity (CC(50)>50 microM).
Related Publications
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
October 2004,
Journal of medicinal chemistry,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
January 2008,
Nucleic acids symposium series (2004),
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
August 2017,
Bioorganic & medicinal chemistry letters,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
May 2015,
Organic & biomolecular chemistry,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
October 2011,
Bioorganic & medicinal chemistry letters,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
January 2007,
Antiviral chemistry & chemotherapy,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
January 2016,
ACS medicinal chemistry letters,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
December 2016,
ACS medicinal chemistry letters,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
February 2019,
Journal of medicinal chemistry,
Esmir Gunic, and
Jean-Luc Girardet, and
Kanda Ramasamy, and
Vesna Stoisavljevic-Petkov, and
Suetying Chow, and
Li-Tain Yeh, and
Robert K Hamatake, and
Anneke Raney, and
Zhi Hong
May 2012,
Bioorganic & medicinal chemistry letters,
