-transparent.png){kind=logo}
Recently, gastrinoma cells were demonstrated to release gastrin when directly stimulated by secretin both in vivo and in vitro. In this study, the reaction of antral G cells was investigated. Secretin was injected into the right gastroepiploic artery in canines, and into the common hepatic artery during a selective arteriography in patients without gastrinomas. G cells obtained from the antrum of rats were attached to 0.45-microns filters and irrigated with medium containing secretin. The serum gastrin concentration increased rapidly in significant amounts and very quickly after an intraarterial injection of secretin, both in humans and in dogs. The rate of gastrin release from the rat antral G cells in vitro increased significantly when the medium contained secretin. In conclusion, secretin stimulated gastrin release from antral G cells both in vivo and in vitro.
Y Hattori, and
M Imamura, and
T Tobe
December 1982,
Digestive diseases and sciences,
Y Hattori, and
M Imamura, and
T Tobe
June 1980,
The Australian and New Zealand journal of surgery,
Y Hattori, and
M Imamura, and
T Tobe
June 2000,
European journal of gastroenterology & hepatology,
Y Hattori, and
M Imamura, and
T Tobe
August 1997,
The American journal of physiology,
Y Hattori, and
M Imamura, and
T Tobe
August 1999,
The Journal of biological chemistry,
Y Hattori, and
M Imamura, and
T Tobe
July 1990,
Gastroenterology,
Y Hattori, and
M Imamura, and
T Tobe
January 1995,
Digestion,
Y Hattori, and
M Imamura, and
T Tobe
February 1997,
Gastroenterology,
Y Hattori, and
M Imamura, and
T Tobe
January 1990,
The Journal of clinical investigation,
Y Hattori, and
M Imamura, and
T Tobe
April 1987,
European journal of clinical investigation,
