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Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 +/- 3.6 years and 53.3% +/- 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159 +/- 0.017 for the patients and 0.017 +/- 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
June 2003,
The Journal of surgical research,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
October 2006,
Gut,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
January 2004,
The Journal of trauma,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
October 1990,
Burns : journal of the International Society for Burn Injuries,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
January 1994,
Arquivos de gastroenterologia,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
June 1984,
Infection and immunity,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
February 1994,
Surgery,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
April 1990,
Surgery,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
August 1992,
Journal of pediatric surgery,
T LeVoyer, and
W G Cioffi, and
L Pratt, and
R Shippee, and
W F McManus, and
A D Mason, and
B A Pruitt
April 1992,
Burns : journal of the International Society for Burn Injuries,
