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The electrophysiological effects of oxidized low density lipoproteins (ox-LDLs) have been studied in rabbit Purkinje fibers using standard microelectrode techniques, in comparison with native LDLs (n-LDLs) and lysophosphatidylcholine (LPC). At the concentration of 100 micrograms protein/ml, ox-LDL but never n-LDL induced the abrupt occurrence of abnormal electrical activities during the basic stimulation of 1 Hz (6/13 fibers) and the development of either early afterdepolarizations (6/13 fibers) or abnormal automaticity (4/13 fibers) at low frequencies (0.1 and 0.03 Hz). Short trains of rapid stimulation (2, 3, 4 and 5 Hz) did not trigger delayed afterdepolarizations. However, early afterhyperpolarizations were commonly seen after each action potential. 30 microM LPC caused quite similar electrophysiological derangements. The results suggest that ox-LDLs may exert arrhythmogenic effects partly explained by their LPC content.
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
January 1995,
Journal of molecular and cellular cardiology,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
October 2011,
American journal of physiology. Gastrointestinal and liver physiology,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
January 2015,
Gastroenterology research and practice,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
August 1999,
Clinica chimica acta; international journal of clinical chemistry,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
February 1999,
International journal of impotence research,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
July 2004,
Rheumatology international,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
September 1996,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
January 2008,
Cardiology,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
April 2004,
The Journal of clinical endocrinology and metabolism,
M M Adamantidis, and
L Moreau-Guedon, and
F Martin-Nizard, and
H Sqalli-Houssaini, and
P Duriez, and
J C Fruchart, and
B Dupuis
January 2002,
Physiological research,
