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We measured antigen levels of 2 kinds of plasminogen activator, tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (UK), as well as those of their primary inhibitors, type-I plasminogen activator inhibitor (PAI-1) and type-2 plasminogen activator inhibitor (PAI-2), in tissue extracts from benign and malignant breast tumors. Tumor tissue samples from 40 fibroadenomas and 40 breast cancers were examined. t-PA antigen levels were the same in the 2 groups. Malignant tumors contained higher levels of UK antigen than did benign tumors. In the case of breast cancer, UK antigen levels of tumors with axillary lymph-node involvement were significantly higher than those of tumors without lymph-node involvement. PAI-1 and PAI-2 antigen levels of breast-cancer tissue samples were higher than those of fibroadenoma samples. PAI-1 antigen levels of carcinomas with lymph-node involvement were also significantly higher than those of carcinomas without node involvement. PAI-2 antigen levels, on the contrary, were higher in carcinomas without node involvement. UK, PAI-1 and PAI-2 antigen levels are potentially excellent independent factors for prediction of the metastatic potential of breast cancers.
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
January 1984,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
January 1982,
Cancer research,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
July 2005,
Oncology reports,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
May 1995,
International journal of cancer,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
March 2013,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
January 1999,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
February 1992,
Biochemical Society transactions,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
April 1990,
Biochemical Society transactions,
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
January 1991,
In vivo (Athens, Greece),
K Sumiyoshi, and
K Serizawa, and
T Urano, and
Y Takada, and
A Takada, and
S Baba
September 1995,
Arteriosclerosis, thrombosis, and vascular biology,
