The response of three cell types (human fibroblasts, monocytes, and platelets), cultured or seeded onto different intraocular lens materials, was analyzed by ultrastructural examination. The materials considered were poly(methyl methacrylate) (PMMA), heparin surface-modified PMMA, plasma-treated PMMA, and hydrogel. Significant differences in density and distribution of the cultured cells were demonstrated among these materials. The ultrastructure of the cells appeared to be normal, except in one case. Disorganization of the points of focal contact and of the cytoskeletal elements was found in the fibroblasts cultured onto all materials except PMMA. Morphological evidence of cell activation was observed for some materials, but this requires confirmation by more specific immunocytochemical tests.