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The nocturnal gastric acid secretion of 22 male duodenal ulcer patients was compared with that of 47 healthy male volunteers. Median nocturnal acid output was greater in duodenal ulcer patients (55 mmol versus 33 mmol 10 h-1; p = 0.013), but there was almost complete overlap of the ranges. Five duodenal ulcer patients and three volunteers had nocturnal outputs of acid previously considered to be pathognomonic of the Zollinger-Ellison syndrome in the absence of other evidence of a gastrinoma. Nineteen healthy volunteers underwent a repeat study to assess the reproducibility of nocturnal gastric acid output. Median intraindividual variability (+/- distribution-free 95% confidence limits) was 23% (-34% to +72%). Studies of nocturnal gastric secretion are of no diagnostic value, and their variability should be taken into consideration when evaluating gastric antisecretory drugs.
E J Boyd, and
K G Wormsley
March 1964,
Polski przeglad chirurgiczny,
E J Boyd, and
K G Wormsley
January 1984,
Acta gastroenterologica Latinoamericana,
E J Boyd, and
K G Wormsley
September 1994,
The Indian journal of medical research,
E J Boyd, and
K G Wormsley
October 1984,
British journal of clinical pharmacology,
E J Boyd, and
K G Wormsley
July 1946,
Gastroenterology,
E J Boyd, and
K G Wormsley
November 1948,
Gastroenterology,
E J Boyd, and
K G Wormsley
January 1981,
Scandinavian journal of gastroenterology,
E J Boyd, and
K G Wormsley
March 1948,
Archives of surgery (Chicago, Ill. : 1920),
E J Boyd, and
K G Wormsley
April 1976,
The New England journal of medicine,
E J Boyd, and
K G Wormsley
January 1981,
The American journal of the medical sciences,
