Ambiguus motoneurons innervating laryngeal and esophageal muscles are malpositioned in the Reelin-deficient mutant rat, Shaking Rat Kawasaki. 2007

Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
Department of Otorhinolaryngology, Kyoto Prefectual School of Medicine, Kyoto, Japan.

CONCLUSIONS The present study confirmed that ambiguus motoneurons innervating intrinsic laryngeal and esophageal muscles are radially malpositioned in the brainstem of the Shaking Rat Kawasaki (SRK), a reelin-deficient mutant rat. OBJECTIVE Ambiguus motoneurons innervating the striated muscles of the larynx and esophagus take a long migration from their original birth plate in the floor of the fourth ventricle to their final settlement in the ventral margin of the medulla oblongata. To examine whether the migration of ambiguus nucleus neurons is affected in SRK, we studied localization of ambiguus motoneurons of postnatal day 21 (P21) normal and SRK rats. METHODS To label ambiguus motoneurons retrogradely, horseradish peroxidase (HRP) was injected into some laryngeal muscles including cricothyroid, thyroarytenoid and posterior cricoarytenoid muscles, and the cervical and abdominal esophageal muscles of the SRK and normal controls 2 days before sacrifice. RESULTS In the P21 normal rat, HRP-positive laryngeal and esophageal motoneurons were found in the nucleus ambiguus, whereas in the P21 SRK, they were scattered from the base of the fourth ventricle to the ventro-lateral margin of the medulla, suggesting that radial migration of ambiguus motoneurons from their birthplace to their final settlement is guided by Reelin protein.

UI MeSH Term Description Entries
D007821 Laryngeal Muscles The striated muscle groups which move the LARYNX as a whole or its parts, such as altering tension of the VOCAL CORDS, or size of the slit (RIMA GLOTTIDIS). Cricothyroid Muscles,Aryepiglottic Muscle,Arytenoid Muscle,Cricoarytenoid Muscles,Thyroarytenoid Muscles,Thyroepiglottic Muscle,Vocal Muscle,Vocalis Muscle,Aryepiglottic Muscles,Arytenoid Muscles,Cricoarytenoid Muscle,Cricothyroid Muscle,Laryngeal Muscle,Muscle, Aryepiglottic,Muscle, Arytenoid,Muscle, Cricoarytenoid,Muscle, Cricothyroid,Muscle, Laryngeal,Muscle, Thyroarytenoid,Muscle, Thyroepiglottic,Muscle, Vocal,Muscle, Vocalis,Muscles, Aryepiglottic,Muscles, Arytenoid,Muscles, Cricoarytenoid,Muscles, Cricothyroid,Muscles, Laryngeal,Muscles, Thyroarytenoid,Muscles, Thyroepiglottic,Muscles, Vocal,Muscles, Vocalis,Thyroarytenoid Muscle,Thyroepiglottic Muscles,Vocal Muscles,Vocalis Muscles
D009046 Motor Neurons Neurons which activate MUSCLE CELLS. Neurons, Motor,Alpha Motorneurons,Motoneurons,Motor Neurons, Alpha,Neurons, Alpha Motor,Alpha Motor Neuron,Alpha Motor Neurons,Alpha Motorneuron,Motoneuron,Motor Neuron,Motor Neuron, Alpha,Motorneuron, Alpha,Motorneurons, Alpha,Neuron, Alpha Motor,Neuron, Motor
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D011922 Rats, Mutant Strains Rats bearing mutant genes which are phenotypically expressed in the animals. Mutant Strains Rat,Mutant Strains Rats,Rat, Mutant Strains,Strains Rat, Mutant,Strains Rats, Mutant
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D004947 Esophagus The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
D006735 Horseradish Peroxidase An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology. Alpha-Peroxidase,Ferrihorseradish Peroxidase,Horseradish Peroxidase II,Horseradish Peroxidase III,Alpha Peroxidase,II, Horseradish Peroxidase,III, Horseradish Peroxidase,Peroxidase II, Horseradish,Peroxidase III, Horseradish,Peroxidase, Ferrihorseradish,Peroxidase, Horseradish
D000091042 Reelin Protein It is an EXTRACELLULAR MATRIX serine protease that plays an important role in the development of the central nervous system. It regulates neuronal migration and microtubule function. RELN Protein,Reeler Protein,Protein, RELN,Protein, Reeler,Protein, Reelin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
October 2001, The Journal of comparative neurology,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
May 1981, Neuroscience letters,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
May 1984, Experimental neurology,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
November 1998, Brain research,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
July 1997, The Journal of comparative neurology,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
March 1997, Brain research. Molecular brain research,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
December 1998, The Annals of otology, rhinology, and laryngology,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
August 2003, The Journal of comparative neurology,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
June 1987, Experimental neurology,
Kaheita Hirasugi, and Yasuo Hisa, and Tomiyoshi Setsu, and Toshio Terashima
June 1996, The Journal of comparative neurology,
Copied contents to your clipboard!