-transparent.png){kind=logo}
The effect of a thromboxane A2 synthetase inhibitor (OKY-046, 400 mg po/day) on mucociliary transport was investigated in 19 asthmatic patients. The nasal clearance time, as measured by the saccharin test, was prolonged in asthmatics (60.2 +/- 8.4 SE min) compared with normal controls (15.1 +/- 3.4 SE min). Within 4 weeks after OKY-046 administration, the nasal clearance time had improved (27.4 +/- 4.4 SE min, P less than .01) and the amount of sputum had decreased 30% (P less than .01). These results indicate that thromboxane A2 plays an important role in mucociliary transport in patients with asthma.
Related Publications
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
June 1986,
Experientia,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
November 1993,
Surgery,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
January 1991,
The Journal of asthma : official journal of the Association for the Care of Asthma,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
April 1990,
International journal of clinical pharmacology, therapy, and toxicology,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
November 1994,
Chest,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
July 1986,
Japanese journal of pharmacology,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
May 1986,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
August 1990,
European journal of pharmacology,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
May 1996,
Transplantation,
K Kurashima, and
H Ogawa, and
T Ohka, and
M Fujimura, and
T Matsuda
October 1995,
The European respiratory journal,
