-transparent.png){kind=logo}
Microcrystals of monosodium urate monohydrate (MSUM) induce cytolysis and hemolysis in erythrocytes. In this report, we studied the effect of vitamin E on MSUM-mediated hemolysis in human erythrocytes. Vitamin E significantly inhibited hemolysis induced by MSUM. The hydroxyl group in the chromanol ring of vitamin E is dispensable for protecting erythrocytes against hemolysis induced by MSUM, indicating that the inhibitory effect of vitamin E is not due to its antioxidant properties. However, both the chromanol ring and the isoprenoid side chain are important for vitamin E to suppress MSUM-induced hemolysis. Our current study suggests that vitamin E inhibits hemolysis induced by MSUM as a membrane stabilizer.
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
January 1980,
Advances in experimental medicine and biology,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
April 1976,
Journal of the American Chemical Society,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
June 1983,
The Journal of rheumatology,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
October 2003,
Arthritis and rheumatism,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
February 2019,
Chemical communications (Cambridge, England),
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
June 1979,
Arthritis and rheumatism,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
November 2002,
Arthritis and rheumatism,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
May 1996,
Biochimica et biophysica acta,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
August 1986,
The Journal of rheumatology,
Qiong Xie, and
Shude Li, and
Weiyang Feng, and
Yongzhi Li, and
Yuanliang Wu, and
Wei Hu, and
Youguang Huang
August 1988,
Rheumatic diseases clinics of North America,
