Biomaterial Database

[Reye's syndrome: pathological study of 2 cases]. 1975

C Pagis de Micco, and P Chapoy, and H Perrimond, and G Lebreuil

The authors report two personal cases of Reye's syndrome, one of which was studied by electron microscopy, and comment on the pathological characteristics of this disease. The hepatic lesions are most important and resemble fatty degeneration rather than simple steatosis. This notion is confirmed by data obtained by electron microscopy which revealed marked abnormalities of the cellular organites, in particular, mitochondria. The nervous involvement included mainly, oedema of the nerve sheath. These facts emphasize the importance of metabolic disturbances in the physiopathology of the disease.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D001927	Brain Diseases	Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	Intracranial Central Nervous System Disorders,Brain Disorders,CNS Disorders, Intracranial,Central Nervous System Disorders, Intracranial,Central Nervous System Intracranial Disorders,Encephalon Diseases,Encephalopathy,Intracranial CNS Disorders,Brain Disease,Brain Disorder,CNS Disorder, Intracranial,Encephalon Disease,Encephalopathies,Intracranial CNS Disorder
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012202	Reye Syndrome	A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.	Fatty Liver with Encephalopathy,Reye Syndrome, Adult,Reye's Syndrome,Reye's Syndrome, Adult,Reye's-Like Syndrome,Reye-Johnson Syndrome,Reye-Like Syndrome,Adult Reye Syndrome,Adult Reye's Syndrome,Reye Johnson Syndrome,Reye Like Syndrome,Reye's Like Syndrome