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Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. 2007
Carmen D Zorrilla, and
Russell Van Dyke, and
Arlene Bardeguez, and
Edward P Acosta, and
Betsy Smith, and
Michael D Hughes, and
Sharon Huang, and
D Heather Watts, and
Barbara Heckman, and
Eleanor Jiménez, and
George McSherry, and
Lynne Mofenson
Obstetrics and Gynecology Department, UPR School of Medicine, P.O. Box 365067, San Juan, Puerto Rico. czorrilla@rcm.upr.edu
Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).
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