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We studied changes in rat lung fibronectin (FN) content and synthesis after endobronchial administration of elastase. A severe hemorrhagic neutrophilic alveolitis ensued with plasma protein leakage, initial rise in tissue FN content, and sustained rise in FN synthesis. Unlike fibrotic models where initial rises in tissue FN levels are sustained, levels in this model normalized promptly. This, in the setting of increased synthesis is consistent with increased degradation. This degradation of tissue FN may result in the disruption of the lung architecture, interfere with the deposition of newly synthesized matrix and could partly explain the development of emphysema in a model where excess fibronectin synthesis is observed.
B A Dubaybo, and
L A Crowell, and
L A Thet
February 1986,
Research communications in chemical pathology and pharmacology,
B A Dubaybo, and
L A Crowell, and
L A Thet
January 1999,
Canadian respiratory journal,
B A Dubaybo, and
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January 1985,
Annual review of medicine,
B A Dubaybo, and
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February 2008,
Respiratory physiology & neurobiology,
B A Dubaybo, and
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L A Thet
November 1989,
Laboratory investigation; a journal of technical methods and pathology,
B A Dubaybo, and
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January 1987,
Pediatric pulmonology,
B A Dubaybo, and
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L A Thet
January 1992,
Experimental lung research,
B A Dubaybo, and
L A Crowell, and
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January 1987,
Journal of toxicology and environmental health,
B A Dubaybo, and
L A Crowell, and
L A Thet
January 1977,
Advances in experimental medicine and biology,
B A Dubaybo, and
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L A Thet
August 2008,
Shock (Augusta, Ga.),
