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Six patients with metastatic malignant melanoma were treated systemically with dacarbazine and interleukin-2 (IL-2). During IL-2 administration all patients developed a macular erythematous rash followed by scaling which began 24-48 h after IL-2 infusion. The dermatological changes were associated with elevated interferon-gamma and tumor necrosis factor alpha serum levels (immunoradiometric assay). Histology revealed nonspecific spongiotic foci in the epidermis and a perivascular mononuclear infiltrate in the dermis. Immunohistochemistry characterized this infiltrate mainly as activated T helper lymphocytes and revealed the expression of intercellular adhesion molecule 1 by endothelial cells and keratinocytes that might have been induced by interferon-gamma. The skin reactions associated with systemic IL-2 administration, show that the skin actually participates as a target organ. They should be differentiated from drug eruptions.
R Dummer, and
K Miller, and
C Eilles, and
G Burg
January 1988,
Intensive care medicine,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
April 2011,
Annals of neurology,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
January 2012,
Annals of neurology,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
January 1991,
Journal of the National Cancer Institute,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
January 2006,
Proteomics,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
April 2006,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
May 1993,
Scandinavian journal of immunology,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
January 1965,
Giornale italiano di dermatolotia. Minerva dermatologica,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
February 2009,
Der Internist,
R Dummer, and
K Miller, and
C Eilles, and
G Burg
July 1994,
Fortschritte der Medizin,
