-transparent.png){kind=logo}
Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors. 2007
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP-10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. zhao_hongyu@hotmail.com
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening.
Related Publications
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
February 2013,
Bioorganic & medicinal chemistry letters,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
April 2016,
Nature chemical biology,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
August 2009,
Bioorganic & medicinal chemistry letters,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
February 2015,
Bioorganic & medicinal chemistry,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
July 2003,
Biology of reproduction,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
May 2016,
Chemistry and physics of lipids,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
September 2020,
Journal of medicinal chemistry,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
September 2009,
Expert opinion on therapeutic patents,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
June 2003,
Current opinion in lipidology,
Hongyu Zhao, and
Michael D Serby, and
Harriet T Smith, and
Ning Cao, and
Tom S Suhar, and
Teresa K Surowy, and
Heidi S Camp, and
Christine A Collins, and
Hing L Sham, and
Gang Liu
January 2010,
Current topics in medicinal chemistry,
