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Immunoreactive plasma human prolactin (HPr) and human growth hormone (HGH) concentrations were measured in six normal young men with polygraphic sleep monitoring during normal sleep and during sleep in which l-dihydroxyphenylalanine (l-DOPA) was infused intravenously at a rate of 0.8 to 1.0 mg/min. The intravenous infusion of l-DOPA significantly suppressed the episodic release of HPr during sleep and the occurrence of rapid eye movement (REM) sleep. However, HGH release during sleep was not remarkably influenced by l-DOPA. These results suggest that central catecholaminergic neural mechanisms are related to both sleep-related HPr release and REM sleep, but do not play an important role in sleep-related HGH release.
K Chihara, and
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K Maeda, and
S Ohgo, and
H Imura
September 1975,
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K Chihara, and
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August 1975,
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K Chihara, and
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K Chihara, and
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September 1978,
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K Chihara, and
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November 1979,
The Journal of clinical endocrinology and metabolism,
K Chihara, and
Y Kato, and
K Maeda, and
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January 1974,
Neuroendocrinology,
K Chihara, and
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January 1978,
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K Chihara, and
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October 1971,
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K Chihara, and
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Nihon Naibunpi Gakkai zasshi,
