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The sensitizing properties of brucella 31 kD and 31+15 kD protein antigens produced by Escherichia coli cell carrying and expressing the corresponding brucella genes were compared. In experiments evaluating the test of mouse feet oedema in CBA line animals the property of the 31 kD antigen preparation to induce the specific oedema effect was demonstrated on the level comparable with the one produced by the brucella outer membrane proteins preparation. The obtained data were confirmed in the experiments on adoptive transfer of prolonged type hypersensitivity via the spleen cells from the sensitized donors to intact recipient animals. The future of molecular cloning technique usage for obtaining the homogeneous stable preparations of brucella antigens with low reactivity and high specificity is discussed.
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
January 1992,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
December 1992,
Protein science : a publication of the Protein Society,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
January 1979,
Acta biochimica Polonica,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
September 1960,
Virology,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
September 1990,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
January 1985,
Annual review of biochemistry,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
January 1989,
Journal of cell science. Supplement,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
January 1977,
European journal of biochemistry,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
January 1980,
Molecular & general genetics : MGG,
V E Malikov, and
D F Seliutina, and
V N Gorelov, and
V A Chibisova, and
E A Dranovskaia
May 1981,
Journal of general microbiology,
