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A previously healthy 44-year-old man died three weeks after the simultaneous onset of encephalitis and retinitis. Fundus changes were bilateral and included papillitis, rapidly progressive central retinal vein obstruction, and massive exudative retinal detachment. A 16-fold rise in herpesvirus hominis antibodies occured between the 10th and 20th days of illness. At autopsy, the brain showed changes characteristic of herpetic encephalitis, and cultures of the brain yielded Herpesvirus hominis type I. Intranuclear inclusion bodies typical of those produced by Herpesvirus were found by light microscopy in brain, optic nerves, retina, and choroid. Herpesvirus particles were found by electron microscopy in brain, optic nerve, and retina.
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
November 1972,
British medical journal,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
November 1970,
Archives of neurology,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
January 1973,
Neurology,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
March 1970,
Journal of immunology (Baltimore, Md. : 1950),
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
December 1982,
Journal of the American Veterinary Medical Association,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
March 1970,
The Journal of pediatrics,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
July 1973,
Medicine,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
December 1973,
The Journal of infectious diseases,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
April 1970,
Southern medical journal,
D S Minckler, and
E B McLean, and
C M Shaw, and
A Hendrickson
September 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
