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From an immunological point of view during pregnancy the interactions between the steroid sex hormones and immunocompetent cells as a part of the dynamic local and peripheral immune response is of a particular interest. The aim of our study is to investigate the expression of the early activation marker CD69 in T-lymphocytes subpopulation: CD4+ and CD8+ in peripheral blood from pregnant and non-pregnant women. Our data clearly demonstrate an increase of the percentage of activated CD4+ lymphocytes in pregnant women in comparison to non-pregnant and this difference is statistically significant. A similar but not statistically significant dependency is observed in CD8+ and CD69+ lymphocytes. From the obtained results we conclude that during pregnancy the activation of CD4+ lymphocytes is increased, which probably leads to an increased production of cytokines that shifts the immune response to Th2 type which is protective for pregnancy. This could be partly due to the increased levels of progesterone.
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
January 1976,
Bollettino dell'Istituto sieroterapico milanese,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
January 1986,
Physiologie (Bucarest),
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
January 2001,
Gynecologic and obstetric investigation,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
February 1984,
Scandinavian journal of haematology,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
October 1983,
Archives of pathology & laboratory medicine,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
June 1976,
Bollettino della Societa italiana di biologia sperimentale,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
January 1974,
International archives of allergy and applied immunology,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
June 1984,
Cellular immunology,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
January 1983,
Biological research in pregnancy and perinatology,
E I Ivanova-Todorova, and
N Aĭvazova, and
Ts R Mekhandzhiev, and
A Nalbanski, and
T Chernev, and
D S Kiurkchiev
July 1983,
Veterinary immunology and immunopathology,
