Biomaterial Database

[Histoenzymatic study of the liver and submandibular gland of rats exposed to sodium fluoride in drinking water]. 2006

Ewa Dabrowska, and Maria Balunowska, and Rafał Letko

Zaklad Stomatologii Spolecznej i Profilaktyki Akademii Medycznej w Białymstoku ul. Akademicka 3, 15-089 Białystok

OBJECTIVE Universal use of fluorine compounds in dentistry, as well as industrial and civilization-related exposures may produce undesirable effects of fluorine action. The effects of fluoride ions depend on the dose and exposure time. Some may be positive, e.g. in caries prevention, while others are harmful when optimal prophylactic or therapeutic doses have been surpassed. The literature is replete with reports on interactions of fluoride ions with the activity of many enzymes and indirectly with cellular metabolism. METHODS The paper presents the results of a histoenzymatic study of the liver and submandibular gland of young rats exposed to NaF administered in drinking water. The intensity of staining for lactate dehydrogenase, succinate dehydrogenase, acid and alkaline phosphatase was evaluated. RESULTS The reaction to succinate dehydrogenase in the submandibular gland and lactate dehydrogenase in hepatocytes was attenuated, while the reaction to acid phosphatase was enhanced in the liver when rats were exposed to 32.0 mg NaF/dm(3) of drinking water.

UI	MeSH Term	Description	Entries
D007770	L-Lactate Dehydrogenase	A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.	Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260	Female		Females
D005457	Fluoridation	Practice of adding fluoride to water, and other food or beverages, for the purpose of preventing DENTAL CARIES.	Milk Fluoridation,Salt Fluoridation,Water Fluoridation,Fluoridation, Milk,Fluoridation, Salt,Fluoridation, Water
D006651	Histocytochemistry	Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.	Cytochemistry
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000469	Alkaline Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.