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2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: new potent inhibitors of fMLP-induced neutrophil chemotaxis. 2007
Olga Bruno, and
Chiara Brullo, and
Francesco Bondavalli, and
Angelo Ranise, and
Silvia Schenone, and
Maria Sofia Falzarano, and
Katia Varani, and
Susanna Spisani
Dipartimento di Scienze Farmaceutiche, Università di Genova, Genova, Italy. obruno@unige.it <obruno@unige.it>
It is well known that both acute and chronic autoimmune inflammatory disorders arise following a breakdown in control of neutrophil activation and recruitment. In the search for new anti-inflammatory agents, we synthesized some new 2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives and tested them in vitro in order to evaluate their ability to interfere with human neutrophil functions. All tested compounds showed strong inhibition of fMLP-OMe-induced chemotaxis, although they appeared unable to block degranulation and the fMLP-OMe-induced respiratory burst, and were inactive in binding experiments.
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