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A simple modification of the method of Rossiter and Palmer for the quantitative determination of phosphoinositides (PI) in animal tissues (brain and liver) is worked out: Phospholipids are mineralyzed (together with a paper) in 57% perchloric acid, avoiding the time consuming procedure of the tenfold elution of inositids spots from chromatogramms and the subsequent evaporation of the substantial volume of the eluate obtained. The time of the analysis is twice as short as that of the original method, the data obtained being reliable. The quantity of mono-, di- and triphosphoinositides in rat brain is as follows: 85.08, 11.33 and 32.85 mkg P/g wet tissue, but in liver it is 94.5, 1.88 and 2.5 mkg P/g wet tissue respectively.
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
January 1975,
Voprosy meditsinskoi khimii,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
January 1947,
Federation proceedings,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
January 1991,
Psychopharmacology bulletin,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
March 1985,
Biochemical and biophysical research communications,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
April 1961,
The Biochemical journal,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
March 1991,
Biochemical and biophysical research communications,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
July 1987,
Biochemical and biophysical research communications,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
February 2013,
CNS & neurological disorders drug targets,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
March 2011,
Journal of the neurological sciences,
O M Amirkhanian, and
L T Amirkhanian, and
K G Karagezian
June 2002,
Neuroscience letters,
