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Age-specific salivary immunoglobulin A response to Streptococcus mutans GbpB. 2007
Ruchele D Nogueira, and
Alessandra C Alves, and
William F King, and
Reginaldo B Gonçalves, and
José F Höfling, and
Daniel J Smith, and
Renata O Mattos-Graner
Department of Oral Diagnosis, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.
In a follow-up study of children infected with Streptococcus mutans at an early age (children previously shown to respond poorly to S. mutans GbpB), there was a delay in their immune response, rather than a complete inability to respond to this antigen. Epitopes in the N-terminal third of GbpB were identified as targets for naturally induced immunoglobulin A antibody in children at an early age.
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