-transparent.png){kind=logo}
Some properties of the macromolecules of the KCl-extracts of the nuclei of the uterus, kidney, liver, testis and prostate, specifically binding estradiol (E2), were studied. These macromolecules of the uterus and the liver were found to be maximally extracted from chromatin by the 0.6 M KCl concentration. The capacity of the macromolecules of the uterine, kidney and liver nuclear extracts to bind E2 specifically is destroyed completely by pronase, but not by RNA-ASe and DNA-ase, pointing to the protein nature of these macromolecules. Only estrogenic compounds, but not testosterone, 5alpha-dihydrotestosterone, progesterone or corticosterone were capable to compete with H3--E2 for the E2--binding sites of the macromolecules of the nuclear extracts of all the organs investigaeted. It is assumed that macromolecules of the nuclei of the investigated nontarget organs specifically binding E2 are estrogen receptors.
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
May 1987,
Arkhiv anatomii, gistologii i embriologii,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
January 2001,
Radiatsionnaia biologiia, radioecologiia,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
November 1980,
Molecular and cellular endocrinology,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
January 1978,
Fiziolohichnyi zhurnal,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
February 1985,
Cancer letters,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
January 1978,
Fiziologicheskii zhurnal,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
November 2002,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
March 1982,
Clinica chimica acta; international journal of clinical chemistry,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
October 1984,
Fertility and sterility,
A N Smirnov, and
O V Smirnova, and
U M Fisher, and
B V Rozen
September 1982,
Lancet (London, England),
