Mismatch negativity analysis in drug-resistant epileptic patients implanted with vagus nerve stimulator. 2007

D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
Department of Neuroscience, Clinical Neurology, Pisa University School of Medicine, Via Roma, 67, 56126 Pisa, Italy. davz77@tin.it

It is well known that some epileptic patients does not respond to conventional treatments, despite multiple combination of antiepileptic drugs, and they are therefore considered drug-resistant. For these patients, vagal nerve stimulation (VNS) represents a successful alternative to traditional therapy, and it is generally well tolerated; beside benefits on seizure frequency, VNS showed positive effects on cognition and mood. Aim of this study was to investigate short-term memory changes in a group of 12 patients implanted with VNS, through Mismatch Negativity wave (MMN). After 1 year of follow-up, MMN latencies and amplitudes did not show significant changes following VNS implantation, independently on current intensity, as compared with pre-implantation values. In two patients, MMN values, which were abnormal before VNS implantation, showed a major reduction in latency and an increase in amplitude after implantation, suggesting a likely positive effect of VNS on pre-attentive processes investigated by MMN.

UI MeSH Term Description Entries
D008297 Male Males
D008570 Memory, Short-Term Remembrance of information for a few seconds to hours. Immediate Recall,Memory, Immediate,Working Memory,Memory, Shortterm,Immediate Memories,Immediate Memory,Immediate Recalls,Memories, Immediate,Memories, Short-Term,Memories, Shortterm,Memory, Short Term,Recall, Immediate,Recalls, Immediate,Short-Term Memories,Short-Term Memory,Shortterm Memories,Shortterm Memory,Working Memories
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011597 Psychomotor Performance The coordination of a sensory or ideational (cognitive) process and a motor activity. Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D003627 Data Interpretation, Statistical Application of statistical procedures to analyze specific observed or assumed facts from a particular study. Data Analysis, Statistical,Data Interpretations, Statistical,Interpretation, Statistical Data,Statistical Data Analysis,Statistical Data Interpretation,Analyses, Statistical Data,Analysis, Statistical Data,Data Analyses, Statistical,Interpretations, Statistical Data,Statistical Data Analyses,Statistical Data Interpretations
D004351 Drug Resistance Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration. Resistance, Drug
D004567 Electrodes, Implanted Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body. Implantable Electrodes,Implantable Stimulation Electrodes,Implanted Electrodes,Implanted Stimulation Electrodes,Electrode, Implantable,Electrode, Implantable Stimulation,Electrode, Implanted,Electrode, Implanted Stimulation,Electrodes, Implantable,Electrodes, Implantable Stimulation,Electrodes, Implanted Stimulation,Implantable Electrode,Implantable Stimulation Electrode,Implanted Electrode,Implanted Stimulation Electrode,Stimulation Electrode, Implantable,Stimulation Electrode, Implanted,Stimulation Electrodes, Implantable,Stimulation Electrodes, Implanted
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D004599 Electric Stimulation Therapy Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the detection threshold of the skin to pain. Electrotherapy,Electrical Stimulation Therapy,Interferential Current Electrotherapy,Therapeutic Electric Stimulation,Therapeutic Electrical Stimulation,Therapy, Electric Stimulation,Electric Stimulation, Therapeutic,Electrical Stimulation, Therapeutic,Electrotherapy, Interferential Current,Stimulation Therapy, Electric,Stimulation Therapy, Electrical,Stimulation, Therapeutic Electric,Stimulation, Therapeutic Electrical,Therapy, Electrical Stimulation
D004827 Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders

Related Publications

D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
September 2021, European annals of otorhinolaryngology, head and neck diseases,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
November 2009, Pediatric neurology,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
October 2006, Seizure,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
February 2007, Neurology,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
October 2001, Seizure,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
July 2016, Revista de neurologia,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
October 2015, Cardiology in the young,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
November 2001, Nederlands tijdschrift voor geneeskunde,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
September 2005, Cochlear implants international,
D Borghetti, and C Pizzanelli, and P Maritato, and M Fabbrini, and S Jensen, and A Iudice, and L Murri, and F Sartucci
April 2002, Seizure,
Copied contents to your clipboard!