Biomaterial Database

Lemierre's syndrome complicating bacterial pharyngitis in a patient with undiagnosed factor XII deficiency. 2007

Veronica Hlibczuk

Department of Emergency Medicine, New York-Presbyterian Hospital, New York, New York 10032, USA.

Internal jugular vein thrombosis occurs as an uncommon complication of oropharyngitis. The following case report describes a previously healthy adult woman who presented with sore throat, left ear pain, and fever. She was initially diagnosed with pharyngitis and inadvertently had blood cultures sent as part of her workup. She was then called back to the Emergency Department the following day for positive growth of the blood culture, and found to have thrombophlebitis of the internal jugular vein on computed tomography scan of the neck. Further workup revealed factor XII deficiency. The clinical course was further complicated by septic pulmonary emboli and disseminated intravascular coagulation. The patient was treated with broad-spectrum antibiotics and anticoagulation and made a full recovery.

UI	MeSH Term	Description	Entries
D007601	Jugular Veins	Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.	Jugular Vein,Vein, Jugular,Veins, Jugular
D010612	Pharyngitis	Inflammation of the throat (PHARYNX).	Sore Throat,Pharyngitides,Sore Throats,Throat, Sore
D011655	Pulmonary Embolism	Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.	Pulmonary Thromboembolism,Thromboembolism, Pulmonary,Embolism, Pulmonary,Embolisms, Pulmonary,Pulmonary Embolisms,Pulmonary Thromboembolisms,Thromboembolisms, Pulmonary
D004211	Disseminated Intravascular Coagulation	A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.	Consumption Coagulopathy,Coagulation, Disseminated Intravascular,Disseminated Coagulation, Intravascular,Intravascular Coagulation, Disseminated,Intravascular Disseminated Coagulation,Coagulation, Intravascular Disseminated,Coagulations, Disseminated Intravascular,Coagulations, Intravascular Disseminated,Coagulopathies, Consumption,Coagulopathy, Consumption,Consumption Coagulopathies,Disseminated Coagulations, Intravascular,Disseminated Intravascular Coagulations,Intravascular Coagulations, Disseminated,Intravascular Disseminated Coagulations
D005175	Factor XII Deficiency	An absence or reduced level of blood coagulation factor XII. It normally occurs in the absence of patient or family history of hemorrhagic disorders and is marked by prolonged clotting time.	Hageman Trait,Coagulation Factor 12 Deficiency,Deficiency, Factor 12,Deficiency, Factor Twelve,Deficiency, Factor XII,Factor 12 Deficiency,Factor Twelve Deficiency,Hageman Factor Deficiency,Deficiencies, Factor 12,Deficiencies, Factor Twelve,Deficiencies, Factor XII,Deficiency, Hageman Factor,Factor 12 Deficiencies,Factor 12 Deficiency,Factor Deficiency, Hageman,Factor Twelve Deficiencies,Factor XII Deficiencies
D005260	Female		Females
D005675	Fusobacterium necrophorum	A species of gram-negative, non-spore-forming bacteria isolated from the natural cavities of man and other animals and from necrotic lesions, abscesses, and blood.	Sphaerophorus necrophorus
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000925	Anticoagulants	Agents that prevent BLOOD CLOTTING.	Anticoagulant Agent,Anticoagulant Drug,Anticoagulant,Anticoagulant Agents,Anticoagulant Drugs,Anticoagulation Agents,Indirect Thrombin Inhibitors,Agent, Anticoagulant,Agents, Anticoagulant,Agents, Anticoagulation,Drug, Anticoagulant,Drugs, Anticoagulant,Inhibitors, Indirect Thrombin,Thrombin Inhibitors, Indirect