OBJECTIVE To compare the cervical microleakage of titanium copings veneered with 3 porcelain-based materials with that of titanium copings veneered with 2 indirect polymeric materials. METHODS Commercially pure, grade 2 titanium was veneered with 3 porcelain systems specially designed for fusing on titanium: Ti22 (Noritake), Triceram (Esprident), and Vitatitankeramik (Vita). Additionally, 2 polymeric materials were used for veneering titanium: Chromasit and Targis (Ivoclar). Four veneer crowns for each titanium-veneer combination were obtained. After storing the specimens in basic fuchsin, the microleakage between titanium and veneer in the cervical area was assessed by measuring the extent of dye penetration within the interface. ANOVA and post hoc statistics were used to analyze the data. RESULTS Chromasit exhibited the highest mean microleakage score (3 +/- 0.816). The least mean microleakage at the interface was recorded for Ti22 porcelain (0 +/- 0.0), followed by Triceram (0.25 +/- 0.50), Vitatitankeramik (0.75 +/- 0.957), and Targis (1.5 +/- 1.732). Only the differences between each porcelain system and Chromasit were significant (P <.05). CONCLUSIONS Within the limitations of this in vitro study, there was no significant microleakage between titanium copings and the porcelain veneers, regardless of the porcelain system. The microleakage between titanium and the polymeric materials depended on the veneering material. Leakage was significantly higher when Chromasit was used.