BIOMAT Database Logo BIOMAT Database Logo

Role of visfatin, insulin-like growth factor-I and insulin in fetal growth. 2007

Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
2nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece.

OBJECTIVE IGF-I and insulin are the main regulators of intrauterine and postnatal growth. Adipose tissue secreted cytokines are implicated in intrauterine growth. The relevant function of the adipocytokine visfatin is unknown. METHODS Serum visfatin, IGF-I and insulin levels were measured by enzyme immunoassays in 40 singleton full-term fetuses and neonates on postnatal days 1(N1) and 4 (N4). RESULTS No significant correlations exist between visfatin and IGF-I or insulin. N1 and N4 visfatin positively correlated with customized (adjusted) birth weight centiles (r=0.511, P=0.021, and r=0.597, P=0.005, respectively). Fetal and N1 IGF-I positively correlated with customized centiles (r=0.608, P<0.001 and r=0.485, P=0.006, respectively). Fetal insulin positively correlated with customized centiles (r=0.654, P=0.021). CONCLUSIONS Potential implication of visfatin in fetal growth is probably not mediated by IGF-I or insulin. Although a more active role cannot be excluded, visfatin may simply represent a marker of fat accumulation.

UI MeSH Term Description Entries
D007230 Infant, Low Birth Weight An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less. Low Birth Weight,Low-Birth-Weight Infant,Birth Weight, Low,Birth Weights, Low,Infant, Low-Birth-Weight,Infants, Low-Birth-Weight,Low Birth Weight Infant,Low Birth Weights,Low-Birth-Weight Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D001724 Birth Weight The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms. Birthweight,Birth Weights,Birthweights,Weight, Birth,Weights, Birth
D005260 Female Females
D005312 Fetal Blood Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery. Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
The role of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in the control of human fetal growth.
January 1992, The Journal of endocrinology,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Transforming growth factor-beta1 in fetal serum correlates with insulin-like growth factor-I and fetal growth.
September 2002, Obstetrics and gynecology,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Spatial and temporal expression of insulin-like growth factor-I, insulin-like growth factor-II and the insulin-like growth factor-I receptor in the sheep fetal mammary gland.
February 1999, The Journal of dairy research,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.
February 2003, Endocrinology,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Insulin-like growth factor binding proteins in fetal rat mesencephalic cultures: regulation by fibroblast growth factor and insulin-like growth factor I.
August 1996, Endocrinology,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.
November 1986, The Journal of biological chemistry,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Insulin-like growth factor I in substrate-deprived, growth-retarded fetal rats.
August 1991, Pediatric research,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
[The effect of insulin-like growth factor I and insulin on intrauterine fetal growth retardation].
April 1999, Zhonghua fu chan ke za zhi,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Insulin-like growth factor I signalling through heterodimers of insulin and insulin-like growth factor I receptors.
January 1994, Diabete & metabolisme,
Despina D Briana, and Maria Boutsikou, and Dimitrios Gourgiotis, and Louiza Kontara, and Stavroula Baka, and Nicoletta Iacovidou, and Dimitrios Hassiakos, and Ariadne Malamitsi-Puchner
Insulin-like growth factor family in malignant haemangiopericytomas: the expression and role of insulin-like growth factor I receptor.
May 1999, The Journal of pathology,
Copied contents to your clipboard!