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We have prospectively evaluated a regimen of mitozantrone and cytosine arabinoside (Ara-C) as first-line therapy in elderly patients with acute myeloid leukaemia (AML). One hundred and four patients with a median age of 68 (range 60-81) were studied, in whom 86 had de-novo AML, and 18 had preceding myelodysplasia or secondary AML. Complete remission was achieved in 64% of de-novo cases, in 28% of MDS/secondary cases, and in 58% overall. The incidence of early death within 28 d of chemotherapy was 11%. The median disease-free survival (DFS) was 11 months with an actuarial DFS of 15% at 43 months. The median overall survival was 9 months with an actuarial survival of 10% at 44 months. The incidence of non-haematological toxicity was acceptably low, and usually of mild to moderate severity. Quality of life was improved, or unchanged, in 90% of responders. We conclude that mitozantrone and ara-C is an effective and well-tolerated regimen which produces high remission rates in elderly patients with AML.
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N G Flanagan, and
D W Gorst, and
M J Lewis
March 1992,
British journal of haematology,
J A Liu Yin, and
P R Johnson, and
J M Davies, and
N G Flanagan, and
D W Gorst, and
M J Lewis
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J A Liu Yin, and
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J A Liu Yin, and
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M J Lewis
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J A Liu Yin, and
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J A Liu Yin, and
P R Johnson, and
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J A Liu Yin, and
P R Johnson, and
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M J Lewis
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J A Liu Yin, and
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J A Liu Yin, and
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J A Liu Yin, and
P R Johnson, and
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N G Flanagan, and
D W Gorst, and
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