[Correlation between intraocular pressure, paquimetry and keratometry in a normal population]. 2007

H Sánchez-Tocino, and R Bringas-Calvo, and D Iglesias-Cortiñas
Departamento de Oftalmología, Hospital Río Hortega, Valladolid, España. hsanchez@auna.es

OBJECTIVE To study the intraocular pressure (IOP), the corneal thickness and the corneal curvature distribution in a normal population. To investigate the relation between these variables, and to determine if the IOP and the paquimetry will be modified by the refractive error and age. METHODS A population of 273 subjects, 545 eyes, without ocular pathology was selected. The refractive error, the corneal curvature, the corneal thickness and the IOP [with a non-contact tonometer (NCT) and with a Goldmann tonometer (GT)] were evaluated. RESULTS The average age of the population was 49.34 (SD 7.23) years (27-68). The average corneal thickness was 544.3 (SD 33) mm in females and 543.1 (SD 29) mm in males. An inverse correlation was found between corneal thickness and age but this was not significant statistically. A mildly statistically significant correlation was found between corneal thickness and intraocular pressure with both methods of measurement of IOP: r = 0.316 (p < 0,001) and r = 0.264 (p < 0,001), with NCT and GT respectively. No correlation was found between corneal thickness and refractive error, or with mean corneal curvature. In the regression model, corneal thickness and mean corneal curvature were significant in the IOP prediction: R = 0.341 (p < 0.001). CONCLUSIONS Mean corneal thickness was very similar to that reported in other studies of a latin population. A statistically significant inferior corneal thickness has been found in people older than 54 years. The relationship between the corneal thickness and the corneal curvature with the IOP has been calculated by linear regression analyses.

UI MeSH Term Description Entries
D007429 Intraocular Pressure The pressure of the fluids in the eye. Ocular Tension,Intraocular Pressures,Ocular Tensions,Pressure, Intraocular,Pressures, Intraocular,Tension, Ocular,Tensions, Ocular
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012029 Refraction, Ocular Refraction of LIGHT effected by the media of the EYE. Ocular Refraction,Ocular Refractions,Refractions, Ocular
D012030 Refractive Errors Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus. Ametropia,Refractive Disorders,Ametropias,Disorder, Refractive,Disorders, Refractive,Error, Refractive,Errors, Refractive,Refractive Disorder,Refractive Error
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D003315 Cornea The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed) Corneas
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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