Biomaterial Database

Neuroprotective effects of alpha2-adrenergic receptor agonists. 2007

Bernd Weber, and Markus Steinfath, and Jens Scholz, and Berthold Bein

Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. weber@anaesthesie.uni-kiel.de

Alpha2-adrenergic receptor agonists exert potent analgesic and sedative/hypnotic effects. In addition, they have been shown to be neuroprotective in various experimental models, but the molecular pathways leading to these actions are still poorly defined. This review summarizes the available literature and discusses potential mechanisms of alpha2-adrenergic receptor agonist mediated neuroprotection.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000322	Adrenergic Agonists	Drugs that bind to and activate adrenergic receptors.	Adrenomimetics,Adrenergic Agonist,Adrenergic Receptor Agonist,Adrenergic Receptor Agonists,Receptor Agonists, Adrenergic,Agonist, Adrenergic,Agonist, Adrenergic Receptor,Agonists, Adrenergic,Agonists, Adrenergic Receptor,Receptor Agonist, Adrenergic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D048288	Imidazolines	Compounds based on reduced IMIDAZOLES containing a single double bond.	Imidazoline
D058647	Adrenergic alpha-2 Receptor Agonists	Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.	Adrenergic alpha-2 Agonists,Adrenergic alpha-2 Receptor Agonist,Adrenergic alpha2-Agonists,Adrenergic alpha 2 Agonists,Adrenergic alpha 2 Receptor Agonist,Adrenergic alpha 2 Receptor Agonists,Adrenergic alpha2 Agonists,Agonists, Adrenergic alpha-2,alpha-2 Agonists, Adrenergic,alpha2-Agonists, Adrenergic
D018696	Neuroprotective Agents	Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.	Neuroprotectant,Neuroprotective Agent,Neuroprotective Drug,Neuroprotectants,Neuroprotective Drugs,Neuroprotective Effect,Neuroprotective Effects,Agent, Neuroprotective,Agents, Neuroprotective,Drug, Neuroprotective,Drugs, Neuroprotective,Effect, Neuroprotective,Effects, Neuroprotective