Biomaterial Database

Takagi Glare Tester CGT-1000 for contrast sensitivity and glare testing in normal individuals and cataract patients. 2007

Konrad Pesudovs

NH&MRC Centre for Clinical Eye Research, Department of Ophthalmology, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia. konrad.pesudovs@flinders.edu.au

OBJECTIVE To investigate the sensitivity and repeatability of the Takagi Contrast Glare Tester CGT-1000 in normal individuals and those with cataracts. METHODS A prospective observational study was performed. The Takagi Contrast Glare Tester measures contrast sensitivity (CS) at 6 target sizes and 13 contrast levels (2.00 to 0.34 logCS). Testing follows a method of descending limits paradigm with a single reversal determining threshold. The CGT-1000 was administered with and without glare in 95 eyes of 61 cataract patients and 13 controls. The percentage floor (unable to see the highest contrast) and ceiling (able to see the lowest contrast) effects and correlations between CS and cataract grades were determined. The repeatability was evaluated using Bland-Altman limits of agreement and expressed as the coefficient of repeatability (COR). Factor analysis was used to test for redundancy within the 6 spatial frequencies. RESULTS In normal individuals, a high rate of ceiling effect varying with target size was noted--for 6.3 degrees, 4.0 degrees, 2.5 degrees, 1.6 degrees, 1.0 degrees, 0.7 degrees, ceiling effects were 68%, 58%, 18%, 11%, 4%, 2%, respectively, for no glare, and 47%, 42%, 8%, 2%, 2%, 2%, respectively, with glare. In cataract patients, floor effects were noted--3%, 0%, 3%, 7%, 19%, 62%, respectively, for no glare, and 3%, 3%, 6%, 14%, 44%, 79%, respectively, with glare. Correlations with cataract grades ranged from 0.10 to 0.61, being best for nuclear cataract. Repeatabilities expressed as COR were +/- 0.11, +/- 0.14, +/- 0.28, +/- 0.38, +/- 0.38, +/- 0.47 logCS, respectively. All spatial frequencies loaded heavily on one factor, indicating no gain in information from testing multiple target sizes. CONCLUSIONS Sensitivity to the presence of cataract was good, but ceiling effects in normal individuals and floor effects in cataract patients limit accuracy. Repeatability was poor, but could be improved by testing less spatial frequencies more rigorously.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D002386	Cataract	Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)	Cataract, Membranous,Lens Opacities,Pseudoaphakia,Cataracts,Cataracts, Membranous,Lens Opacity,Membranous Cataract,Membranous Cataracts,Opacities, Lens,Opacity, Lens,Pseudoaphakias
D003941	Diagnostic Techniques, Ophthalmological	Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.	Diagnostic Technic, Ophthalmological,Diagnostic Technics, Ophthalmologic,Diagnostic Technics, Ophthalmological,Diagnostic Technique, Ophthalmological,Diagnostic Techniques, Ophthalmologic,Ophthalmological Diagnostic Technic,Ophthalmological Diagnostic Technics,Ophthalmological Diagnostic Technique,Ophthalmological Diagnostic Techniques,Technic, Ophthalmological Diagnostic,Technics, Ophthalmological Diagnostic,Technique, Ophthalmological Diagnostic,Techniques, Ophthalmological Diagnostic,Diagnostic Technic, Ophthalmologic,Diagnostic Technique, Ophthalmologic,Ophthalmologic Diagnostic Technic,Ophthalmologic Diagnostic Technics,Ophthalmologic Diagnostic Technique,Ophthalmologic Diagnostic Techniques,Technic, Ophthalmologic Diagnostic,Technics, Ophthalmologic Diagnostic,Technique, Ophthalmologic Diagnostic,Techniques, Ophthalmologic Diagnostic
D004867	Equipment Design	Methods and patterns of fabricating machines and related hardware.	Design, Equipment,Device Design,Medical Device Design,Design, Medical Device,Designs, Medical Device,Device Design, Medical,Device Designs, Medical,Medical Device Designs,Design, Device,Designs, Device,Designs, Equipment,Device Designs,Equipment Designs
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D015203	Reproducibility of Results	The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.	Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015350	Contrast Sensitivity	The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate VISUAL ACUITY and to detect eye disease.	Visual Contrast Sensitivity,Sensitivity, Contrast,Sensitivity, Visual Contrast
D019466	Glare	Relatively bright light, or the dazzling sensation of relatively bright light, which produces unpleasantness or discomfort, or which interferes with optimal VISION, OCULAR. (Cline et al., Dictionary of Visual Science, 4th ed)