Biomaterial Database

Late corneal hydrops after penetrating keratoplasty for keratoconus. 2007

Daniel G Ezra, and Jodhbir S Mehta, and Bruce D Allan

Cornea and External Disease Service, Moorfields Eye Hospital, London, United Kingdom. Daniel_Ezra@hotmail.com

OBJECTIVE To report 2 cases of corneal hydrops occurring in eyes with previously healthy corneal grafts. METHODS Retrospective case series. A report of 2 presenting cases. Both patients underwent a full ophthalmic clinical examination and anterior segment optical coherence tomography (OCT). RESULTS Two patients with longstanding corneal grafts for keratoconus presented with an acute painful red eye and reduced vision. They were found to have acute hydrops with breaks in and detachments of Descemet membrane. CONCLUSIONS Keratoconic patients with longstanding corneal grafts who present acutely with corneal edema must be carefully examined not only for signs of graft rejection or failure but also for acute hydrops. Important differentiating signs may be a Descemet break or detachment and the presence of stromal edema across the donor-host corneal interface.

UI	MeSH Term	Description	Entries
D007640	Keratoconus	A noninflammatory, usually bilateral protrusion and thinning of the CORNEA, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. Two closely related noninflammatory corneal ectasias are pellucid marginal degeneration and keratoglobus.	Keratoglobus,Pellucid Marginal Corneal Degeneration,Pellucid Marginal Degeneration,Degeneration, Pellucid Marginal,Marginal Degeneration, Pellucid,Pellucid Marginal Degenerations
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011183	Postoperative Complications	Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D003886	Descemet Membrane	A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.	Lamina Elastica Posterior,Descemet's Membrane,Descemet Membranes,Descemets Membrane,Elastica Posterior, Lamina,Elastica Posteriors, Lamina,Lamina Elastica Posteriors,Membrane, Descemet,Membrane, Descemet's,Membranes, Descemet,Posterior, Lamina Elastica,Posteriors, Lamina Elastica
D005938	Glucocorticoids	A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.	Glucocorticoid,Glucocorticoid Effect,Glucorticoid Effects,Effect, Glucocorticoid,Effects, Glucorticoid
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D012422	Rupture, Spontaneous	Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.	Ruptures, Spontaneous,Spontaneous Rupture,Spontaneous Ruptures