BIOMAT Database Logo BIOMAT Database Logo

Impression cytology of the conjunctival epithelial cells in patients with cystic fibrosis. 2008

M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Department of Pediatric Ophthalmology, Medical University of Bialystok, Bialystok, Poland. mrugacz1@poczta.onet.pl

OBJECTIVE Cystic fibrosis (CF) is the most frequent lethal autosomal recessive hereditary disorder. The disease affects all secretory epithelia, including the eye, and belongs to the group of ocular surface epithelial diseases, termed keratoconjunctivitis sicca or dry eye syndrome. The aim of this study was to evaluate goblet cell population and conjunctival epithelial morphology in patients with CF. METHODS A total of 20 CF patients and 20 controls underwent conjunctival impression cytology. RESULTS Impression cytology showed conjunctival squamous metaplasia and goblet cell loss in patients with CF. CONCLUSIONS Reduced goblet cell numbers and squamous metaplasia may be indicative of a higher degree of epithelial damage of conjunctival epithelial cells in CF patients, and the presence of neutrophils is a strong sign for an inflammatory background of this disease.In view of the simple, noninvasive nature of impression cytology, this technique may prove to be an important tool for the diagnosis and monitoring of dry eye changes in CF patients.

UI MeSH Term Description Entries
D008297 Male Males
D008679 Metaplasia A condition in which there is a change of one adult cell type to another similar adult cell type.
D002452 Cell Count The number of CELLS of a specific kind, usually measured per unit volume or area of sample. Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003228 Conjunctiva The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball. Bulbar Conjunctiva,Palpebral Conjunctiva,Plica Semilunaris of Conjunctiva,Plicae Semilunares of Conjunctiva,Tunica Conjunctiva,Conjunctiva, Bulbar,Conjunctiva, Palpebral,Conjunctivas
D003550 Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Mucoviscidosis,Cystic Fibrosis of Pancreas,Fibrocystic Disease of Pancreas,Pancreatic Cystic Fibrosis,Pulmonary Cystic Fibrosis,Cystic Fibrosis, Pancreatic,Cystic Fibrosis, Pulmonary,Fibrosis, Cystic,Pancreas Fibrocystic Disease,Pancreas Fibrocystic Diseases
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D015352 Dry Eye Syndromes Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur. Dry Eye,Dry Eye Disease,Evaporative Dry Eye,Evaporative Dry Eye Disease,Evaporative Dry Eye Syndrome,Dry Eye Diseases,Dry Eye Syndrome,Dry Eye, Evaporative,Dry Eyes,Evaporative Dry Eyes

Related Publications

M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Fas expression in conjunctival epithelial cells of patients with cystic fibrosis.
November 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
ICAM-1 expression on conjunctival epithelial cells in patients with cystic fibrosis.
May 2007, Cytometry. Part B, Clinical cytometry,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Conjunctival impression cytology.
January 2013, Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Conjunctival impression cytology.
April 1977, Archives of ophthalmology (Chicago, Ill. : 1960),
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Conjunctival goblet cells in patients with cystic fibrosis.
March 1975, Acta ophthalmologica,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Impression cytology of the conjunctival epithelium in patients with vernal conjunctivitis.
January 1996, Eye (London, England),
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Conjunctival impression cytology in trachoma.
March 2009, Diagnostic cytopathology,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Conjunctival impression cytology in dogs.
January 2005, Veterinary ophthalmology,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
RNA Collection From Human Conjunctival Epithelial Cells Obtained With a New Device for Impression Cytology.
January 2017, Cornea,
M Mrugacz, and I Kasacka, and A Bakunowicz-Lazarczyk, and M Kaczmarski, and W Kulak
Conjunctival impression cytology in patients wearing contact lenses.
May 1997, Cornea,
Copied contents to your clipboard!