Adverse effects of rosemary (Rosmarinus officinalis L.) on reproductive function in adult male rats. 2007

Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid 22110, Jordan. mick@just.edu.jo

Ingestion of rosemary (Rosmarinus officinalis L.) by two groups of adult Sprague-Dawley rats at levels of 250 and 500 mg/kg body wt for 63 days was investigated for its effects on fertility. Body weight and absolute and relative testes weights were not affected, but the average weights of epididymides, ventral prostates, seminal vesicles, and preputial glands decreased significantly. A significant decline in spermatogenesis in testes due to a decrease in the number of primary and secondary spermatocytes and spermatids in treatment group 2 (500 mg/kg) is attributed to a significant decrease in testosterone. Sperm motility and density were also significantly decreased in the cauda epididymis and in the testes of rosemary-treated male rats in group 2. In addition, the treatment markedly increased the number of fetal resorptions in female rats impregnated by group 2 males, thereby reducing their fertility.

UI MeSH Term Description Entries
D008297 Male Males
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D005260 Female Females
D005298 Fertility The capacity to conceive or to induce conception. It may refer to either the male or female. Fecundity,Below Replacement Fertility,Differential Fertility,Fecundability,Fertility Determinants,Fertility Incentives,Fertility Preferences,Fertility, Below Replacement,Marital Fertility,Natural Fertility,Subfecundity,World Fertility Survey,Determinant, Fertility,Determinants, Fertility,Fertility Determinant,Fertility Incentive,Fertility Preference,Fertility Survey, World,Fertility Surveys, World,Fertility, Differential,Fertility, Marital,Fertility, Natural,Preference, Fertility,Preferences, Fertility,Survey, World Fertility,Surveys, World Fertility,World Fertility Surveys
D005837 Genitalia, Male The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM; and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS). Accessory Sex Organs, Male,Genital Organs, Male,Sex Organs, Accessory, Male,Genitals, Male,Reproductive System, Male,Genital, Male,Male Genital,Male Genital Organs,Male Genitalia,Male Genitals,Male Reproductive System,Male Reproductive Systems,Reproductive Systems, Male
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012741 Sexual Maturation Achievement of full sexual capacity in animals and in humans. Sex Maturation,Maturation, Sex,Maturation, Sexual
D013081 Sperm Motility Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression. Motilities, Sperm,Motility, Sperm,Sperm Motilities
D013091 Spermatogenesis The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA. Spermatocytogenesis,Spermiogenesis
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats

Related Publications

Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
November 2016, Nutrients,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
July 2005, Phytochemistry,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
April 2023, Tissue & cell,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
March 2019, Turkish journal of pharmaceutical sciences,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
November 1997, Contact dermatitis,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
January 2019, The journal of physiological sciences : JPS,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
January 2019, Journal of biomedical science,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
January 2024, Journal of ethnopharmacology,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
February 1996, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Mohamad K Nusier, and Hameed N Bataineh, and Haytham M Daradkah
January 2020, The American journal of Chinese medicine,
Copied contents to your clipboard!