Biomaterial Database

Vagal influences on gastric acid secretion in response to gastric distension in the ferret. 1991

M K Naseri, and D Hutson, and D Grundy

Department of Biomedical Science, University of Sheffield, U.K.

The role of the vagus nerve in the stimulation of gastric acid secretion was investigated by comparing the acid output in response to gastric distension during augmented secretion mediated by electrical vagal stimulation and pentagastrin. Under control conditions distension increased acid output from 29.8 +/- 3 mumol/10 min to 59.9 +/- 5.5 mumol/10 min (P less than 0.0001). Bilateral cervical vagotomy significantly reduced both basal acid secretion and the response to distension although the increase during distension was still significant. Electrical vagal stimulation augmented basal acid output and the response to distension, and at 1 Hz both parameters were not different from that before vagotomy. However, the sensitivity of the response to distension was unchanged by vagal stimulation. Pentagastrin infusion augmented basal acid secretion and the response to distension in a similar manner to vagal stimulation. We conclude that the vagus nerves potentiate the gastric acid secretory response to distension not by facilitating enteric reflexes but by an action at the level of the parietal cell.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010418	Pentagastrin	A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	Acignost,Gastrin Pentapeptide,Peptavlon,Pentapeptide, Gastrin
D010812	Physical Stimulation	Act of eliciting a response from a person or organism through physical contact.	Stimulation, Physical,Physical Stimulations,Stimulations, Physical
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005260	Female		Females
D005289	Ferrets	Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.	Domestic Polecat,Domestic Polecats,European Polecat,European Polecats,Ferret,Mustela putorius,Mustela putorius furo,Polecat, Domestic,Polecat, European,Polecats, Domestic,Polecats, European
D005744	Gastric Acid	Hydrochloric acid present in GASTRIC JUICE.	Hydrochloric Acid, Gastric,Acids, Gastric,Acids, Gastric Hydrochloric,Gastric Acids,Gastric Hydrochloric Acid,Gastric Hydrochloric Acids,Hydrochloric Acids, Gastric
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013270	Stomach	An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.	Stomachs
D014628	Vagotomy	The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.	Vagotomies