Biomaterial Database

[Mechanisms and toxic effects of lead on the cardiovascular system]. 2006

Marcin Zawadzki, and Rafał Poreba, and Paweł Gać

Katedra i Zakład Higieny, Akademia Medyczna, Wrocław. zawadzki@hyg.am.wroc.pl

Exposure to lead is still one of essential health problems in our country. Current views on mechanisms and toxic effects of lead on the cardiovascular system are presented. Special attention is paid to changes in the heart morphology and physiology resulting from long-term exposure to lead, the effect of lead on the muscular coat and endothelium of blood vessels, changes in the metabolism of erythrocytes, leukocytes and thrombocytes in persons chronically exposed to lead as well as to the relation between lead and hypertensive and atherosclerotic illnesses induced by changes in the structure and function of the cardiovascular system. The described effects of lead exposure should encourage us to further reduction of occupational and environmental exposure to this metal and controversies that still exist to continue research in this field.

UI	MeSH Term	Description	Entries
D007854	Lead	A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D007855	Lead Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	Poisoning, Lead,Lead Poisonings,Poisonings, Lead
D002318	Cardiovascular Diseases	Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D002319	Cardiovascular System	The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.	Circulatory System,Cardiovascular Systems,Circulatory Systems
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D016273	Occupational Exposure	The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.	Exposure, Occupational,Exposures, Occupational,Occupational Exposures