Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy. 2007

Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. naomiwarren@doctors.org.uk

Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder. In contrast to Parkinson's disease (PD) and dementia with Lewy bodies (DLB), replacement therapy with dopaminergic and cholinergic agents in PSP has been disappointing. The neurochemical basis for this is unclear. Our objective was to measure dopaminergic and cholinergic receptors in the basal ganglia of PSP and control brains. We measured, autoradiographically, dopaminergic (dopamine transporter, 125I PE2I and dopamine D2 receptors, 125I epidepride) and cholinergic (nicotinic alpha4beta2 receptors, 125I 5IA85380 and muscarinic M1 receptors, 3H pirenzepine) parameters in the striatum and pallidum of pathologically confirmed PSP cases (n=15) and controls (n=32). In PSP, there was a marked loss of dopamine transporter and nicotinic alpha4beta2 binding in the striatum and pallidum, consistent with loss of nigrostriatal neurones. Striatal D2 receptors were increased in the caudate and muscarinic M1 receptors were unchanged compared with controls. These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors.

UI MeSH Term Description Entries
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D008297 Male Males
D009662 Nortropanes Derivatives of 8-azabicyclo[3.2.1]octane.
D010890 Pirenzepine An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients. Gastrotsepin,Gastrozepin,L-S 519,LS-519,Piren-Basan,Pirenzepin,Pirenzepin Von Ct,Pirenzepin-Ratiopharm,Pirenzepine Dihydrochloride,Pyrenzepine,Ulcoprotect,Ulgescum,Dihydrochloride, Pirenzepine,LS 519,LS519,Piren Basan,Pirenzepin Ratiopharm,Von Ct, Pirenzepin
D011180 Postmortem Changes Physiological changes that occur in bodies after death. Adipocere,Algor Mortis,Cruor,Livor Mortis,Change, Postmortem,Changes, Postmortem,Postmortem Change
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D011950 Receptors, Cholinergic Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology. ACh Receptor,Acetylcholine Receptor,Acetylcholine Receptors,Cholinergic Receptor,Cholinergic Receptors,Cholinoceptive Sites,Cholinoceptor,Cholinoceptors,Receptors, Acetylcholine,ACh Receptors,Receptors, ACh,Receptor, ACh,Receptor, Acetylcholine,Receptor, Cholinergic,Sites, Cholinoceptive
D011954 Receptors, Dopamine Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells. Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
November 1985, Annals of neurology,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
February 2016, Chinese medical journal,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
January 1991, Neurology,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
April 2002, Neurology,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
January 1990, Neuroscience,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
January 2017, Movement disorders : official journal of the Movement Disorder Society,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
January 2001, Advances in neurology,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
February 2003, Acta neuropathologica,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
January 1994, Journal of neural transmission. Supplementum,
Naomi M Warren, and Margaret A Piggott, and Elizabeth Greally, and Michelle Lake, and Andrew J Lees, and David J Burn
May 1990, Archives of neurology,
Copied contents to your clipboard!