Biomaterial Database

Pathological crying induced by deep brain stimulation. 2007

Lars Wojtecki, and Janpeter Nickel, and Lars Timmermann, and Mohammad Maarouf, and Martin Südmeyer, and Frank Schneider, and Rüdiger J Seitz, and Jürgen Voges, and Volker Sturm, and Alfons Schnitzler

Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.

Pathological crying (PLC)--an affective gesture without any or an adequate emotion--occurs with various diseases. A recent theory suggests that PLC is caused by a disruption of higher order cortical association areas from the cerebellum which computes profiles of psychomotor responses. We report a patient with Parkinson's disease who developed PLC during stimulation of the subthalamic nucleus (STN) predominantly of the right hemisphere. Positron emission tomography imaging showed thalamo-ponto-cerebellar activation during such stimulation. These findings indicate that the STN and possibly also ponto-cerebellar pathways are involved in psychomotor control and in the modulation of PLC.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010300	Parkinson Disease	A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	Idiopathic Parkinson Disease,Lewy Body Parkinson Disease,Paralysis Agitans,Primary Parkinsonism,Idiopathic Parkinson's Disease,Lewy Body Parkinson's Disease,Parkinson Disease, Idiopathic,Parkinson's Disease,Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinsonism, Primary
D003448	Crying	To utter an inarticulate, characteristic sound in order to communicate or express a feeling, or desire for attention.	Cryings
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D001526	Behavioral Symptoms	Observable manifestations of impaired psychological functioning.	Behavioral Symptom,Symptom, Behavioral,Symptoms, Behavioral
D046690	Deep Brain Stimulation	Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously.	Brain Stimulation, Deep,Electrical Stimulation of the Brain,Brain Stimulations, Deep,Deep Brain Stimulations,Stimulation, Deep Brain,Stimulations, Deep Brain