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How the levels of rat cardiac, adrenal, and epinephrine and norepinephrine change with acetaldehyde and ethanol given alone or in combination during their acute and chronic administration was examined. In some series of experiments, acetaldehyde and ethanol were used in combination with teturam. The findings suggest that the coupling of two negative processes--a reduction in cardiac norepinephrine levels, which is associated mainly with the effects produced by ethanol, and an increase in epinephrine concentrations, which is apparently induced by acetaldehyde--may be one of the mechanisms responsible for cardiovascular abnormalities in alcoholic intoxication. Acetaldehyde modifies the regulatory effect of the sympathoadrenal system on cardiac function, causing adrenal catecholamine imbalance.
G Kh Bozhko, and
T P Boĭko
December 1982,
Biulleten' eksperimental'noi biologii i meditsiny,
G Kh Bozhko, and
T P Boĭko
November 1994,
Biochemical Society transactions,
G Kh Bozhko, and
T P Boĭko
January 2013,
Frontiers in behavioral neuroscience,
G Kh Bozhko, and
T P Boĭko
December 1990,
Molecular pharmacology,
G Kh Bozhko, and
T P Boĭko
June 1981,
Metabolism: clinical and experimental,
G Kh Bozhko, and
T P Boĭko
January 1977,
Farmakologiia i toksikologiia,
G Kh Bozhko, and
T P Boĭko
November 1968,
Pathologie et biologie,
G Kh Bozhko, and
T P Boĭko
April 1984,
Experimental and molecular pathology,
G Kh Bozhko, and
T P Boĭko
August 1977,
Biochemistry,
G Kh Bozhko, and
T P Boĭko
May 1972,
Saishin igaku. Modern medicine,
