BIOMAT Database Logo BIOMAT Database Logo

Endocrine stress response in rats subjected to singular orbital puncture while under diethyl-ether anaesthesia. 1991

H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Department of Laboratory Animal Science, State University of Utrecht, The Netherlands.

In an attempt to assess possible discomfort in rats subjected to orbital puncture while under diethyl-ether anaesthesia, their endocrine stress response was determined. Concentrations of corticosterone, adrenaline and noradrenaline were measured in plasma obtained via a jugular catheter from rats subjected to diethyl-ether anaesthesia with or without orbital puncture. No statistically significant differences were found between the punctured and non-punctured rats as to peak levels of plasma corticosterone and adrenaline as well as for the times required by the increased concentrations to return to baseline values. The rate by which the plasma noradrenaline level returned to baseline values was somewhat decreased by orbital puncture. Diethyl-ether anaesthesia alone produced a marked endocrine response when compared with handling and novelty stress associated with the induction of anaesthesia. It is concluded that diethyl-ether anaesthesia causes pronounced increases in the plasma levels of the selected stress hormones and that orbital puncture does not amplify this response. It is suggested that diethyl-ether anaesthesia masks any effects of orbital puncture.

UI MeSH Term Description Entries
D008297 Male Males
D009638 Norepinephrine Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D009915 Orbit Bony cavity that holds the eyeball and its associated tissues and appendages. Eye Socket,Eye Sockets,Orbits,Socket, Eye,Sockets, Eye
D011677 Punctures Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures. Micropunctures,Micropuncture,Puncture
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D004837 Epinephrine The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D004986 Ether A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes. Diethyl Ether,Ether, Ethyl,Ethyl Ether,Ether, Diethyl
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Endocrine stress response in jugular-vein cannulated rats upon multiple exposure to either diethyl-ether, halothane/O2/N2O or sham anaesthesia.
April 2002, Laboratory animals,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Inhalation anaesthesia: from diethyl ether to xenon.
January 2008, Handbook of experimental pharmacology,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Cardiac output response to altered acid-base status during diethyl ether anaesthesia.
November 1975, Canadian Anaesthetists' Society journal,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
The effects of ether anaesthesia on oxidative stress in rats--dose response.
June 1993, Toxicology,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Peripheral vascular changes during diethyl ether anaesthesia.
April 1968, Anaesthesia,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Reduced synthesis of hepatic and plasma proteins in rats during diethyl ether anaesthesia.
April 1984, Acta pharmacologica et toxicologica,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Blood proteolytic activity (proteolysis) in patients operated on under balanced anaesthesia with diethyl ether.
January 1974, Anaesthesia, resuscitation, and intensive therapy,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Death While under Ether.
August 1877, The American journal of dental science,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Liver reaction after halothane and diethyl ether anaesthesia.
January 1967, Acta anaesthesiologica Scandinavica,
H van Herck, and V Baumans, and S F de Boer, and J van der Gugten, and A B van Woerkom, and A C Beynen
Pituitary-adrenal response in male rats subjected to continuous ether stress and the effect of dexamethasone treatment.
November 1977, The Journal of endocrinology,
Copied contents to your clipboard!