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Leaves of Maytenus species are commonly used in Brazil for the treatment of gastric ulcers, dyspepsias and other gastric problems. The present study evaluated the antiulcerogenic potential of a boiling water extract of equal parts of M. aquifolium and M. ilicifolia leaves against ulcer lesions induced by indomethacin and cold-restraint stress in rats. Ranitidine and cimetidine were used as reference drugs. The oral and intraperitoneal administration of the extract had a potent antiulcerogenic effect against both types of ulcers. The extract was shown to cause an increase in volume and pH of gastric juice of the animals with the pH effects comparable to those of cimetidine. The results tend to confirm the popular use of the plant.
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
August 1991,
Journal of ethnopharmacology,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
September 2001,
Journal of ethnopharmacology,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
September 2004,
Journal of ethnopharmacology,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
September 2007,
Journal of ethnopharmacology,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
January 1983,
Neuropsychobiology,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
January 1983,
Neuropsychobiology,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
January 2008,
Archives of pharmacal research,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
January 2011,
Journal of natural science, biology, and medicine,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
July 2005,
Journal of natural products,
M L Souza-Formigoni, and
M G Oliveira, and
M G Monteiro, and
N G da Silveira-Filho, and
S Braz, and
E A Carlini
January 1973,
Jikken dobutsu. Experimental animals,
