BIOMAT Database Logo BIOMAT Database Logo

IgG antibody profile to c-terminal region of Plasmodium vivax merozoite surface protein-1 in Thai individuals exposed to malaria. 2007

Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Naturally acquired immune response to C-terminal region of Plasmodium vivax merozoite surface protein1 (PvMSP1) in 200 individuals with recent clinical episodes of malaria from malaria endemic areas along Thai-Myanmar border in the west and Thai-Cambodia border in the east of Thailand was evaluated by enzyme-linked immunosorbent assay (ELISA). The anti-PvMSP1-IgG antibody was observed in 110 individuals (55%). Among IgG responders, IgG1 coexpressed with IgG3 were the predominant subclasses. The levels of anti-PvMSP1 total IgG, IgG1 and IgG3 antibody response seem to be increased with age although no detectable significant correlation was found (r = 0.004, p = 0.484 for total IgG; r = 0.035, p = 0.386 for IgG1; r = -0.600, p = 0.142 for IgG2; r = 0.077, p = 0.227 for IgG3; r = 0.664, p = 0.051 for IgG4). However, the mean level of specific total IgG was highest in the age group of >40 years. These levels of either specific total IgG or each IgG isotype did not vary among individuals with different malaria episodes. A higher level of specific total IgG, IgG1 and IgG3 antibody response related with the lower of parasitemia density was observed although no significant correlation was found. Our data indicate that individuals exposed to vivax malaria in Thailand developed antibodies to the potential candidate vaccine antigen, PvMSP1 (C-terminal).

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007155 Immunologic Factors Biologically active substances whose activities affect or play a role in the functioning of the immune system. Biological Response Modifier,Biomodulator,Immune Factor,Immunological Factor,Immunomodulator,Immunomodulators,Biological Response Modifiers,Biomodulators,Factors, Immunologic,Immune Factors,Immunological Factors,Modifiers, Biological Response,Response Modifiers, Biological,Factor, Immune,Factor, Immunological,Factors, Immune,Factors, Immunological,Modifier, Biological Response,Response Modifier, Biological
D010966 Plasmodium vivax A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions. Plasmodium vivaxs,vivax, Plasmodium
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000913 Antibodies, Protozoan Immunoglobulins produced in a response to PROTOZOAN ANTIGENS. Protozoan Antibodies
D000953 Antigens, Protozoan Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered. Protozoan Antigens

Related Publications

Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria.
May 1997, Infection and immunity,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Naturally acquired antibody responses to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in Korea.
January 2001, Clinical and diagnostic laboratory immunology,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Naturally acquired IgM antibody response to the C-terminal region of the merozoite surface protein 1 of Plasmodium vivax in Korea: use for serodiagnosis of vivax malaria.
December 2008, The Journal of parasitology,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Plasmodium vivax merozoite surface protein 1 C-terminal recombinant proteins in baculovirus.
April 1994, Molecular and biochemical parasitology,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Human IgG responses against the N-terminal region of the Merozoite Surface Protein 1 of Plasmodium vivax.
January 1992, Memorias do Instituto Oswaldo Cruz,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
IgG subclasses pattern and high-avidity antibody to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in an unstable hypoendemic region in Iran.
October 2009, Acta tropica,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
N-terminal Plasmodium vivax merozoite surface protein-1, a potential subunit for malaria vivax vaccine.
January 2013, Clinical & developmental immunology,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Analysis of naturally acquired antibody responses to the 19-kd C-terminal region of merozoite surface protein-1 of Plasmodium vivax from individuals in Sanliurfa, Turkey.
May 2008, The American journal of tropical medicine and hygiene,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
IgG isotype to C-terminal 19 kDa of Plasmodium vivax merozoite surface protein 1 among subjects with different levels of exposure to malaria in Brazil.
April 2005, Parasitology research,
Nada Pitabut, and Jarinee Panichakorn, and Yuvadee Mahakunkijcharoen, and Chakrit Hirunpetcharat, and Sornchai Looareesuwan, and Srisin Khusmith
Serological detection of Plasmodium vivax malaria using recombinant proteins corresponding to the 19-kDa C-terminal region of the merozoite surface protein-1.
November 2003, Malaria journal,
Copied contents to your clipboard!