BIOMAT Database Logo BIOMAT Database Logo

Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents. 2008

Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Department of Chemistry, Mangalore University, Mangalagangothri, Konaje, Mangalore, Karnataka 574199, India.

A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, (1)H NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D013055 Spectrophotometry, Infrared Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) IR Spectra,Infrared Spectrophotometry,IR Spectras,Spectra, IR
D013844 Thiazoles Heterocyclic compounds where the ring system is composed of three CARBON atoms, a SULFUR and NITROGEN atoms. Thiazole
D016339 Spectrometry, Mass, Fast Atom Bombardment A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information. Fast Atom Bombardment Mass Spectrometry,Fast Atom Bombardment Mass Spectroscopy,Mass Spectrometry, Fast Atom Bombardment,Mass Spectroscopy, Fast Atom Bombardment,Spectroscopy, Mass, Fast Atom Bombardment

Related Publications

Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents.
March 2003, European journal of medicinal chemistry,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis of some new 2-(3-pyridyl)-4,5-disubstituted thiazoles as potent antimicrobial agents.
April 2013, European journal of medicinal chemistry,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles.
November 2010, European journal of medicinal chemistry,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents.
January 2011, European journal of medicinal chemistry,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
September 2011, European journal of medicinal chemistry,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis of some new bis-thiazoles as possible anticancer agents.
December 2002, Die Pharmazie,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Facile synthesis and biological assays of novel 2,4-disubstituted hydrazinyl-thiazoles analogs.
May 2016, Molecular diversity,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
A facile synthesis of 2,4-disubstituted thiazoles using MnO2.
November 2009, Molecules (Basel, Switzerland),
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents.
January 2010, Acta poloniae pharmaceutica,
Prakash Karegoudar, and Mari Sithambaram Karthikeyan, and Dasappa Jagadeesh Prasad, and Manjathuru Mahalinga, and Bantwal Shivarama Holla, and Nalilu Sucheta Kumari
Synthesis of 3,5-disubstituted pyridines as antimicrobial agents.
July 1995, Die Pharmazie,
Copied contents to your clipboard!